ScrewAttack originally started in 2006 with one program, SideScrollers, an audio podcast hosted by the site's creators "Stuttering" Craig Skistimas and "Handsome" Thomas Hanley. Over time, additional shows have been added and removed. Current programs on ScrewAttack.com include The Angry Video Game Nerd, ScrewAttack Europe, Guru Larry's Retro Corner, Video Game Vault, Nametags, Life In A Game, Top 10's, Jose's Puntos, "The Scoop!", Hard News, VGR, SideScrollers, and The Armory. Past features include Art in Gaming, Pwned!, and Captain S. In February 2007, MTV Networks acquired rights to some of ScrewAttack’s programming (Top 10's, Video Game Vault and the Angry Video Game Nerd) adding it to their GameTrailers service. Since working with GameTrailers, ScrewAttack's features have been downloaded over 103 million times.
Putting an emphasis on community, ScrewAttack's users are referred to as "g1s". All g1s are encouraged to participate on the site by creating their original videos for "g1 Submission Sunday", where users submit their videos for possible posting on the website.