When legal issues complicate matters that stall a life-saving bone marrow transplant, Sharon Goodwin (S. Epatha Merkerson) must decide whether to disobey direct orders or stand by and put a patient's life in jeopardy. April (Yaya DaCosta) tends to a caring, homeless man who Dr. Charles (Oliver Platt) evaluates, only to come to an unusual diagnosis that explains his recent behavior. Dr. Natalie Manning's (Torrey DeVitto) parents (guest stars Michael Hendricks and Regan Rohde) come to town to see their new grandchild, much to the dismay of her mother-in-law, Helen (guest star Annie Potts). Dr. Connor Rhodes (Colin Donnell) treats a couple who are injured on their first date by a hit-and-run driver, who Dr. Halstead (Nick Gehlfuss) discovers has his own reasons for causing the accident.
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