At the end of the last series Zoe had just come through pioneering surgery to transplant one of her chest muscles into her arm. The programme follows her over months of physiotherapy to see whether the operation has worked.
Born with spina bifida, all through primary school Emily has been happy to wear pull-up nappies. Now Emily has decided to go ahead with the major surgery that doctors have told her is the only way to regulate when she goes to the toilet.
Nathan spent his primary years spent in mainstream schools, but now his parents must decide whether inclusion is still best for their son, who has Down's Syndrome.
Last year Hamish and his parents moved to the South Island of New Zealand. Hamish had to leave the friends he had grown up with and adapt to a new school where his achondroplasia (or dwarfism) would not be so familiar. At school he became the centre of attention for a few weeks. But with one of New Zealand's great skiing fields on his doorstep, and with Hamish's developing indefatigability, he finds a new pursuit that makes him feel at home.
And Shelbie enjoys a period of good health, before a scare leads to further tests and more treatment.
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