Many different cartoon stars like Bugs Bunny, the Muppet Babies and Garfield join forces to convince Michael, a teenage boy that drugs aren't cool. His sister, Corey, is worried about him because he's started acting differently than he used to. Many of her cartoon tie-in toys come to life, to help find her stolen piggy bank, ending up in the boy's room, finding Michael's stash of drugs, and also finding out that Michael was the one who stole Corey's money to buy marijuana! The various cartoon characters then proceed to band together, and take Michael on a fantasy journey to teach him the risks a life of drug-use can bring.
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