Tsukune Aono, a subpar student both academically and physically, is accepted into a mysterious high school. On his first day of school he meets a girl named Moka Akashiya, who reveals she is really a vampire. Tsukune quickly discovers that his new school is a school for monsters. No one knows Tsukune is human and he tries to figure a way to escape from the school. However, Tsukune's life becomes more complicated when he becomes involved in a fight with a delinquent student and accidently removes the cross on Moka's neck.
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