Horatio and Delko head to Brazil to try and catch Marisol's killer, Antonio Riaz. While in Rio, Horatio reunites with Yelina and learns that his brother Raymond is in too deep undercover in a drug ring run by Riaz. To make matters worse, Horatio's nephew, Ray Jr., is working as a drug mule for Riaz. With the stakes set high, Horatio must catch Riaz before he takes the life of another member of Horatio's family. Meanwhile, in Miami, Natalia butts heads with Ryan as she struggles through her first case as a field agent..
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