The Ghostbusters have to go to the hospital after a job at a chemical plant. The bust at the plant causes a strange chemical to cover the guys, which results in a thick-layer of slime and muck to cover everything but their heads. What's more, the slime seems to react to Slimer in a very unusual way, and the doctors at the hospital are less than helpful in dealing with something they have never seen before. The Ghostbusters eventually realize that the slime is actually part of the ghost they tried to bust at the chemical plant, and that it needs ecto-plasm to survive. Which it why it goes after Slimer. Now the guys have to save Slimer before he is eaten.
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