Dr. Rhodes (Colin Donnell) begins his fellowship in cardiothoracic surgery, but gets off on the wrong foot with his challenging new boss, Dr. Latham (guest star Ato Essandoh). Dr. Choi (Brian Tee) navigates life as the new chief resident and finds the road a bit rocky, while Dr. Charles (Oliver Platt) approaches Sarah (Rachel DiPillo) with an interesting opportunity that catches her off-guard. Elsewhere, April (Yaya DaCosta) works to come to terms with her recently discovered illness and Dr. Manning (Torrey DeVitto) deals with a complicated case involving a pregnant woman who was a victim in a high speed collision. Meanwhile, Dr. Halstead (Nick Gehlfuss) takes exception to the actions of fourth-year medical student Jeff Clarke (guest star Jeff Hephner), whose past history with Dr. Manning may be a factor. Sharon Goodwin (S. Epatha Merkerson) tries to pick up the pieces and move on with her life in the aftermath of Bert leaving. Marlyne Barrett also stars.
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