The two cats pursuing Speedy in Cat-Tails for Two are the slow-witted (and injury-causing) Benny and the fully functioning but unfortunate George, both patterned after the characters Lennie and George in the novel Of Mice and Men. George and Benny are walking down a pier looking for food, when they find a Mexican ship. Figuring the ship will have plenty of Mexican mice, i.e. "Mexican food" (Benny: "It gives me the heartburn and I love it!"), they climb on, only to find an unkempt mouse calling himself "Speedy Gonzalez [sic]: Fastest Mouse in All Mexico".
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